MECHANISM OF ACTION OVERVIEW - RPRx
Recycling Polycarbonyl Redox Therapy
This class of novel proprietary compounds represents a new platform of investigational drug candidates.
By driving mitochondrial metabolism, RPRx induces a recycling redox mechanism in abnormally proliferating or disabled cells until normal signaling mechanisms are restored.
This process either leads to metabolism of intracellular debris and prenylated cross-linkages (fixing the diseased cell) or drives diseased cell to apoptosis (programmed cell death).
Healthy cells have enzymatic mechanisms that prevent over expression of the RPRx mechanism of action.
Thus, the core mechanism of action selectively targets diseased cells, rather than healthy cells.
Results from Anecdotal animal studies
Equine Myeloencephalitis (EPM)
• 311 horses treated with intravenous administration of this class of compounds.
• 296 horses (95%) asymptomatic within 7-14 days.
• Mode of mechanism suggests apoptosis of neoplastic tissue (without necrosis)
• 6 of 6 horses completely resolved with no complications.
Johne’s Disease: Chronic Inflammation
• 2 of 2 bulls resolved with no complications.